Research theme 12
Biological Modelling & Experimental Drug Discovery
Investigating candidate therapies using research models, with explicit limitations when translating model observations to human cancer.
Connected investigational workflow Linked to an OnKommon research-use workflow. Findings are investigational and not clinical evidence.
Research models can be used to test narrow hypotheses about how specific alterations respond to candidate compounds. OnKommon AVATAR combines computational interpretation with an investigational fruit-fly modelling and candidate-drug screening process. Results are research findings, not evidence that a treatment works in a person.
Questions of interest
- Which hypotheses are narrow and measurable enough for a model study?
- What controls and endpoints make model results interpretable?
- How should limitations be stated when communicating model observations?
Approaches
- Hypothesis refinement before any model work
- Predefined controls and measurable endpoints
- Written limitations statements for every output
Connection to clinical services
Connected to OnKommon AVATAR, labelled investigational and research use only.
Limitations
- A response in a model is not proof of efficacy, safety or likely response in a person.
- Model findings must not be used to make individual treatment decisions.
Projects and outputs
No verified projects or publications are listed for this theme yet.